Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns.

CpGs with higher methylation levels in tumor tissues were more likely to be within CpG islands (Fisher’s Exact Test, p -value 3.44e–154, OR = 1.18, 95% CI = 1.18–1.12), and statistically significant CpGs were also found in greater proportion in gene regulatory regions (promoter, first exon, or first intron) than in gene body regions (other exon, other intron, or 3′ proximal region), although this association did not reach statistical significance.

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