Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence.

Oncogene · 2017 · PMC5393973 · PMID 27748766

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quite significantno p-value reported

The implications for a loss of hormone receptor signaling and dependence are likely to be quite significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.