Anti-citrullinated protein antibodies are associated with decreased bone mineral density: baseline data from a register of early arthritis patients.

Cumulative disease activity was significantly associated with bone loss at lumbar spine and it showed a trend to significance at hip and ultradistal forearm, but no association was observed at mid forearm which is mainly cortical bone [ 20 ].

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In addition, this population showed a higher disease activity that reached statistical significance with HUPI and was almost significant when estimated by DAS28 (Table 1 ).

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