DNA Methyltransferase Gene Polymorphisms for Prediction of Radiation-Induced Skin Fibrosis after Treatment of Breast Cancer: A Multifactorial Genetic Approach.

The Kaplan-Meier analysis of model 5 revealed that patients with an increasing sum risk score showed a trend towards higher frequencies of grade ≥ 2 fibrosis (p trend=0.0005) ( Fig. 3 ).

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When applying the score developed in model 5, the proportion of patients with grade ≥ 2 radiation-induced fibrosis for each score group showed an increasing trend from lower to higher sum risk scores: 3.4% (score 0), 10.0% (score 1), 14.0% (score 2), and 27.3% (score 2).

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