Joint genetic analysis using variant sets reveals polygenic gene-context interactions.

This interaction was located within 400kb of an interaction identified in a large meta study (66,185 individuals [ 34 ]), which reports both an association for C-reactive protein at the same locus (P<6x10 -11 ) as well as a nominally significant interaction with sex (P<5x10 -3 ).

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Briefly, opposite effects were defined by three criteria, i) marginal significance in both contexts, ii) LD between contexts (r2>0.8) and iii) negative correlation of genetic effects.

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