Standard association analysis is based on the χ 2 statistic, which is skewed by low-frequency alleles and can result in highly significant P values (type I error).
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Novel linkage disequilibrium clustering algorithm identifies new lupus genes on meta-analysis of GWAS datasets.
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The sentences
Two novel genes identified using OASIS were nominally significant, RBFOX1 and MON2 / PPM1H .