Effect of the CES1 c.662A>G SNP on the PK of oseltamivir The mean metabolic ratio of oseltamivir was approximately 13% lower in subjects with the c.662AG genotype than in subjects with the c.662AA genotype, although this effect failed to reach statistical significance ( Fig 2 , Table 1 ).
← all excerpts
The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans.
1
—
—