From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine.

Curr Pharm Des · 2016 · PMC5403958 · PMID 27592718

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The PCSK9 mechanism of action is believed to be related to its binding to LDLR on the surface of the cell shifting the equilibrium to lysosomal-dependent degradation rather than recycling LDLR from the endosome to the cell membrane, which suggests PCSK9 function can be quite significant in targeting LDLR degradation [ 10 ]. 1.3.

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