Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis.

There were modest differences (lower ALP in HCA subjects) at later time-points that did not reach statistical significance (HCA vs Non-HCA, week 2 p = 0.26; week 3, p = 0.24; week 4, p = 0.59, analysis as described for Fig 4 ) Late onset sepsis is associated with significant elevation of plasma ALP Subjects were categorized as No LOS (culture negative and CRP<15 mmol/l, 78 subjects), suspected contamination (culture positive and CRP<15, 0 subjects), possible LOS (culture negative and CRP>15, 18 subjects), and definite LOS (positive culture and CRP>15, 29 subjects).

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