showed a trendP = 0.028
The difference in p53 immunostaining between adenoma and carcinoma was significant ( P = 0.001). Association of TUFM and p53 expression with clinicopathologic features in colorectal adenoma Upon statistical analysis, a significant difference was found in TUFM expression according to histologic type of adenomas; TUFM showed a trend of more frequent positivity in tubulovillous adenoma (60%) compared with the other three types of adenoma (tubular, 33.3%; villous, 57.7%; serrated, 55.6%; P = 0.028).