Immune dysregulation may contribute to disease pathogenesis in spinal muscular atrophy mice.

Hum Mol Genet · 2017 · PMC5409095 · PMID 28108555

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However, the progression of events leading to what appears to be a loss of white pulp formation remains to be determined. The thymus is decreased in size in symptomatic Smn 2B/- mice but not in Smn -/- ;SMN2 mice Our comparison of the various organs showed a trend towards a decrease in the ratio of the thymus weight over mouse weight in Smn 2B/- mice at P19 ( Supplementary Material , Fig. 4 ).

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