Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.

Of the 1025 meta-analyses performed, 50 (5%) resulted nominally statistically significant (p<.05), whereas the remaining 975 did not reach statistical significance.

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rs10165970 is an intronic G>A SNP which showed a highly significant association with cancer in general according to the mixed primary meta-analysis (including 20338 subjects) although an intermediate level of evidence due to insufficient magnitude of association (summary OR: 1.1, CI: 1.03-1.17, P=.002), FPRP was low classifying this SNP as “noteworthy”.

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