CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance.

Although the mRNA levels of PGC-1α and UCP-1 in Creg1 +/- mice fed with HFD decreased more than the wild-type mice, the difference did not reach statistical significance ( Fig 5E ).

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The pro-inflammatory chemokine MCP-1 showed a tendency of increase in Creg1 +/- mice but failed to reach significance, suggesting that reduction of CREG1 may affect some cytokine expression even on a normal diet ( Fig 5A ).

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