From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.

Toxicol Sci · 2017 · PMC5414856 · PMID 28123102

Europe PMC DOI

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showed a trendno p-value reported

RTR2996 tissue levels increased with dose from 5 to 15 mg/kg and showed a trend for saturation at 45 mg/kg.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.