Conditional Depletion of Hippocampal Brain-Derived Neurotrophic Factor Exacerbates Neuropathology in a Mouse Model of Alzheimer's Disease.

Quantitative analysis confirmed the rostral LC had a statistically significant decline (27%) of average intensity of TH staining in BDNF KO sections compared with controls ( Figure 3(c) ), while a smaller decrease (roughly 25%) in the caudal LC did not reach statistical significance ( Figure 3(d) ).

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