Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems.

Although several metabolites including alanine, asparagine, glutamate, glutamine and glutathione did not reach statistical significance after false discovery rate correction, they showed differential levels between the PLF and PSF groups ( P <0.05), which supports a glutamatergic pathway activity difference between the two groups.

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