Novel and Effective Therapeutic Regimens for <i>Helicobacter pylori</i> in an Era of Increasing Antibiotic Resistance.

Additionally, a significant trend toward a decreasing prevalence of H. pylori infection was observed in studies that included only urban populations (Nagy et al., 2016 ).

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pylori infection rates in patients with upper gastrointestinal symptoms in 1999 and 2012 found a decreasing trend in the prevalence of H. pylori infection, i.e., 69.7% in 1999 and 45.2% in 2012 (Darko et al., 2015 ).

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Similarly, an increasing trend of antibiotic resistance (e.g., to amoxicillin, tetracycline, levofloxacin, and moxifloxacin) was also observed (Lee J.

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