Paternal age effects on sperm FOXK1 and KCNA7 methylation and transmission into the next generation.

Hum Mol Genet · 2016 · PMC5418740 · PMID 28171595

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showed a trendno p-value reported

The FOXK1 promoter showed a trend for accelerated demethylation in the autism group.

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borderline significantno p-value reported

The remaining five genes and LINE-1 elements did not show a significant correlation between average methylation (of the entire target region) and paternal age, although a few individual CpG sites, for example CpG2 ( P = 0.05) in the LINE-1 assay, were borderline significant.

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