Dioxins and related environmental contaminants increase TDP-43 levels.

Mol Neurodegener · 2017 · PMC5420162 · PMID 28476168

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It is notable that FICZ also increased expression of SOD1 and showed a trend for FUS, which raises the possibility that environmental AHR ligands might impact on a variety of genes linked to ALS and be an important environmental modifier of disease incidence or progression.

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