Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence.

Although no significant drug-by-group interactions were found, the effects of GSK598809 appeared to be largely driven by effects within the abstinent drug-dependent groups rather than controls (especially within the DRD3-rich VP where a strong trend to an interaction was observed).

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MID fMRI Effect of task The reward-neutral contrast for each group for both the placebo and GSK598809 conditions revealed a highly significant network of activation, including the VP, VS, and SN, in line with previous studies ( Knutson et al , 2000 ).

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