Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery.

Six studies demonstrated a statistically significant reduction in the rate of SSI with the use of topical vancomycin, and two additional studies reported a strong trend in favor of topical antibiotics. 51 - 58 However, one study using propensity score matching demonstrated no difference with the use of topical vancomycin; this was one of only two studies that accounted for potentially confounding variables. 59 Odds ratios for SSI with topical vancomycin ranged from 0.06 to 0.75.

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