Transhepatic arterial infusion chemotherapy using a combination of miriplatin and CDDP powder versus miriplatin alone in the treatment of hepatocellular carcinoma: a randomized controlled trial.

There were no treatment-related deaths in either arm. Although none of the serum concentrations of albumin, total bilirubin, creatinine, or prothrombin time-international normalized ratio (PT-INR) showed a significant trend during the treatment course (Fig. 4 ), a significant reduction in the serum cholinesterase concentration was observed in four out of ten cases receiving the combination therapy ( p < 0.0001, r = 0.86 Fig. 2d and Table 4 ).

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