Genome-wide methylation analysis of a large population sample shows neurological pathways involvement in chronic widespread musculoskeletal pain.

For the same set of 1392 genes, the most highly significant canonical pathways were “Synaptic Long Term Depression” ( P = 1.2e-8), “Axonal Guidance Signaling” ( P = 3.4e-7), “CREB (cAMP response element-binding protein) Signaling in Neurons” ( P = 4.3e-7), “Neuropathic Pain Signaling in Dorsal Horn Neurons” ( P = 4.7e-7), and “Melatonin signalling” ( P = 5e-7).

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Nominally significant ( P < 0.05) Pearson correlations between the repeated measurements (R repeat ) in 292 selected individuals were found for 723,029 bins (lsBINs; 6.3% of the initial 11,524,145 bins).

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