ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.

The differences between control and ALS did not reach statistical significance for p-p38 (Fig. 5C ; p = 0.16) or FUS (Fig. 5D ; p = 0.053) biochemical quantification, likely due to the relatively small number of human cases that were available for this study and the inherent variability of human postmortem tissue, but the trend was consistent with increased p-p38 levels.

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