TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents.

A clear trend towards upregulation of the skin barrier proteins involucrin (IVL, 1.4-fold; p = 0.099; Fig. 2b ) and loricrin (LOR, 1.6-fold; p = 0.5218; Fig. 2c ), as well as the tight junction proteins occludin (OCLN, 1.4-fold, Fig. 2d ) and claudin-1 (CLDN-1, 1.2-fold, p = 0.036, Fig. 2e ) in FLG − compared to FLG + skin equivalents was observed, in line with previous reports from our group 13 .

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