Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ.

9) The differences in gene expression reported in Figure 6C may be significant because of the high number of genes included in the comparison, but these differences are very small and not likely to be biologically important.

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Applying this method, we observed that Dnmt3a-cKO tumors showed a slight increase in the total number of mutations; however, this difference did not reach statistical significance ( Author response image 4 ) We next tried to determine whether there were any differences in the types of mutations among the four bases, between wild type and Dnmt3-cKO tumors.

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