Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.

When Mac-3-positive macrophage areas were expressed as percentage of total lesion areas, the macrophage contents in Apoe −/− Tlr7 +/+ control mice remained higher than those in Apoe −/− Tlr7 −/− mice, but such a difference did not reach statistical significance (26.27 ± 11.34% vs . 10.50 ± 2.51%, P = 0.141) (Fig. 3D ).

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