Rethinking the Appraisal and Approval of Drugs for Fracture Prevention.

Front Pharmacol · 2017 · PMC5430022 · PMID 28555109

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barely statistically significantno p-value reported

Effects on total non-vertebral fractures were barely statistically significant, and depend on inclusion of rib and sternal fractures in the composite endpoint.

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did not reach statistical significanceno p-value reported

Observed hip fracture risk increased with age in the zoledronic acid group compared with placebo, although the trend did not reach statistical significance.

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