Significance of genetic polymorphisms in long non-coding RNA AC079767.4 in tuberculosis susceptibility and clinical phenotype in Western Chinese Han population.

Our analysis showed that patients carrying the homozygous CC genotype of rs12477677 had a highly significant association with fewer frequency of fever ( p = 0.016) among patients with TB, which to a certain extent reflects the host inflammatory response to pathogen invasion.

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The presence of allele C in homozygosis was more common in controls, although the difference did not reach statistical significance ( p > 0.05).

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The minor allele (C allele) frequency of rs12477677 was 46.48% in case group and 50.53% in controls, and the p -value of 0.056 after adjusting for age and gender was borderline significant (OR = 0.85, 95% CI = 0.72–1.00), but the p value was 0.224 after adjustment with Bonferroni correction.

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