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A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic.

Sci Rep · 2017 · PMC5431446 · PMID 28473714

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showed a trendno p-value reported
3C,D ). However, BrdU method of quantifying the highly proliferative neural stem cell population in the telencephalon region of developing fish brain somehow did not yield conclusive result upon the treatment with compounds #3 and #4, except that the 3dpf Zebrafish embryos showed a trend of increased neurogenesis, compared to that treated by the vehicle (Suppl.

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