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Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo.

Sci Rep · 2017 · PMC5431930 · PMID 28496202

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Notably, a trend toward increased activation of the STAT3 pathway was observed following treatment with MEK162, although this did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.