DNA methylation at the mu-1 opioid receptor gene (<i>OPRM1</i>) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion.

Pharmgenomics Pers Med · 2017 · PMC5432115 · PMID 28533693

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showed a trendno p-value reported

Methylation at two CpG sites was associated with both preoperative pain and AUC POD1–2 (CpG 4 and 17); methylation at these sites also showed a trend toward CPSP risk, although not statistically significant.

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