The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia.

In OSU-CLL expressing treRNA, we observed a trend towards less induction of the DNA damage indicator, γH2AX, when exposed to fludarabine or fludarabine plus mafosfamide, but not mafosfamide alone (Figure 4B ), although this did not reach statistical significance ( Supplementary Figure 5B ).

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In vitro studies using the OSU-CLL cell line expressing treRNA showed increased viability and a slight trend towards less induction of the DNA damage marker γH2AX.

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