EGFR mediates activation of RET in lung adenocarcinoma with neuroendocrine differentiation characterized by ASCL1 expression.

Oncotarget · 2017 · PMC5432325 · PMID 28460442

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0550

boldest claim

The sentences

highly significantp < 10 −7actually significant

There was approximately a two-fold down regulation of EGFR in A + AD compared with A − AD which was highly significant (p < 10 −7 ) ( Supplementary Figure 6 ).

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marginally significantp= 0.055so close (0.05 < p ≤ 0.1)

In A + AD on the other hand, EGFR association with OS was significant in a cohort of all stage tumors (p = 0.027) and marginally significant in stage-1 tumors (p= 0.055).

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did not reach statistical significanceno p-value reported

On the other hand, stage did not reach statistical significance most likely because the number of high stage tumors was limited (n=15).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.