An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets.

This replication is quite significant when one considers the very different characteristics of the three datasets (different array platforms, frozen versus paraffin tissue material, somewhat different clinical characteristics with respect to age distribution and the mix of metastatic/nonmetastatic cases, and a relatively small number of recurrence/death events in two of the datasets), which may also explain any minor differences in the findings among the three datasets.

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