Personalized activity index, a new safety monitoring tool for multiple sclerosis clinical trials.

Mult Scler J Exp Transl Clin · 2015 · PMC5433340 · PMID 28607690

Europe PMC DOI

hedged sentence

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

approached significancep = 0.08so close (0.05 < p ≤ 0.1)

In addition, patients who did not meet the rule-of-five and had an MR-pax between 0.05–0.10 were those experiencing moderate increases in CEL activity; they also had a rather high relapse rate (11/14, 79%). In the fit of a mixed-effects logistic regression allowing an interaction between meeting the rule-of-five and having an MR-pax ≤0.05, the interaction term approached significance ( p = 0.08).

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