Computational approach for deriving cancer progression roadmaps from static sample data.

Kaplan–Meier plots of disease-specific survival for the ten groups identified from the METABRIC data revealed a clear trend of worsening survival function along the major trajectories to malignancy through normal to basal (node 10 to node 6), or to luminal A dead-end (node 2 to node 8), or to luminal B dead-end (node 2 through nodes 7, 3 to node 9) or through luminal types to HER2+ (node 2 through nodes 7, 3, 1, 5 to node 4) (Figure 4A ).

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