Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice.

Mol Neurodegener · 2017 · PMC5437664 · PMID 28521765

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did not reach statistical significanceno p-value reported

Thiamet G treatment for 4 weeks (from 12 to 16 weeks of age) also led to a reduction of these pathological tau species, although the reduction did not reach statistical significance (Fig. 5a-c ).

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