Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors: Potential application in the treatment of diabetic neuropathy.

With regard to NGF and DFX, preconditioning induced an increase in the protein level of this neuroprotective factor; however, it did not reach statistical significance ( Fig 4B ) (409.5 ± 135.4 pg/ml in the secretome of 150μM DFX preconditioned cells and 362.1 ± 104.1 pg/ml in the secretome of 400μM DFX preconditioned cells, compared to 240.7 ± 34.8 pg/ml in the secretome of non-preconditioned cells).

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