Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer.

Oncotarget · 2017 · PMC5438673 · PMID 28212573

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closest p · 1.8× alpha

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boldest claim

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borderline significantP=0.09so close (0.05 < p ≤ 0.1)

As expected, SLFN11 H score was also correlated with PDX sensitivity (FC=8.639, P=0.03), whereas ATM H score was borderline significant (FC=−3.446, P=0.09; Figure 1F ).

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did not reach statistical significanceno p-value reported

After SLFN11, E-cadherin (a marker commonly associated with EMT status) was the next strongest protein marker correlated with sensitivity (FC=2.24, P=0.158), although this did not reach statistical significance possibly due to the small sample size.

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