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GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis.

Oncotarget · 2017 · PMC5438695 · PMID 28418868

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Limiting dilution assay revealed that overexpression of ALDH1A1 in 5637 cells significantly increased CSCs/CICs frequency, and T24 cells ALDH1A1 overexpressed cells showed tendency of increase CSCs/CICs frequency but the difference did not reach statistical significance (Table 1 ).

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