In contrast, the association of pS18-H1.5 and pS173-H1.2/5 with pluripotency factor gene TSSs in differentiated cells tended to increase or decrease, respectively, but these changes did not reach statistical significance. pS18-H1.5, pS173-H1.2/5 and pS187-H1.4 were associated with different extents with housekeeping gene TSSs in undifferentiated cells, and this did not change significantly upon cell differentiation.
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Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation.
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It may be significant in this regard that H1.0 lacks predicted sites for interphase phosphorylation [ 13 ].