In the cortex of PGC-1α KO mice Sirt3 (Supplementary Figures 4A,C, 10) mRNA and SIRT3 protein levels also showed a decreasing trend, without reaching statistical significance (Figures 5B,D , Supplementary Figure 11), whereas Sirt4 and Sirt5 mRNA levels were evenly distributed (Supplementary Figures S4B,D).
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Comparison of Sirtuin 3 Levels in ALS and Huntington's Disease-Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models.
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Our experiments showed a trend towards reduced Sirt3 mRNA levels in PGC-1α KO mice compared to wt littermate controls.