The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells.

, 0.5, 13, and 12 μM, respectively) values, in MM3 and MM4 cultures induced a statistically significant increase in the number of apoptotic cells compared with vehicle-treated controls that became highly significant after 72 h (MM3, from 8.98 ± 2.8 to 17.71 ± 5.1% and 44.34 ± 10.6%; MM4, from 9.41 ± 1.6 to 13.6 ± 4.0% and 35.57 ± 13.8%) (Fig. 4a ).

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Conversely, sorafenib-induced apoptosis did not reach statistical significance in the highly sensitive MM1 cells (Fig. 4a ).

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