Kidney dysfunction in patients with pulmonary arterial hypertension.

Pulm Circ · 2017 · PMC5448543 · PMID 28680564

Europe PMC DOI

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showed a trendno p-value reported

74 A recent RCT in patients with non-diabetic CKD showed a trend towards slower decline in renal function in patients on Beraprost compared to placebo. 75 Riociguat Riociguat is a novel treatment for PAH that stimulates the soluble guanylate cyclase in vascular SMCs.

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may be significantno p-value reported

Systemic impact of CKD in PAH Regardless of the mechanism(s) involved in CKD in PAH patients, its impact may be significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.