Barely Significant
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Long-term clinical outcomes following treatment with alpha 1-proteinase inhibitor for COPD associated with alpha-1 antitrypsin deficiency: a look at the evidence.

Respir Res · 2017 · PMC5450185 · PMID 28558837

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showed a trendno p-value reported
Although neither trial reported a significant effect of A 1 -PI therapy on pulmonary function, CT analysis showed a trend towards a more favorable effect of treatment, which was suggestive of lung tissue preservation compared with placebo.

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