However, there are two remaining issues that are quite significant, and really need to be addressed before acceptance, as outlined below: 1) One reviewer and the reviewing editor still believe the manuscript still falls short of establishing how, mechanistically, [Ca 2+ ] activates ERK.
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Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca<sup>2+</sup> signaling in the <i>Drosophila</i> midgut.
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