Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality.

Steroid use after diagnosis was also a significantly important factor (overall mortality: HR, 2.55; 95% confidence interval [CI], 1.39–4.69; P =0.003, mortality from respiratory failure: HR, 2.77; 95% CI, 1.39–5.52; P =0.004) ( Online Supplementary Table S1 ), but allogeneic transplantation did not reach statistical significance (overall mortality: HR, 2.09; 95% CI, 0.76–5.81; P =0.16, mortality from respiratory failure: HR, 2.18; 95% CI, 0.67–7.06; P =0.19).

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Since viral culture positivity from biopsy material is generally considered to indicate invasive viral disease for other respiratory viruses and cytomegalovirus (CMV), 24 , 26 , 27 we consider this finding to be highly significant.

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