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Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease.

Sci Rep · 2017 · PMC5451406 · PMID 28566717

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Interestingly, while a trend towards increased plasma cotinine was observed in both Hhip +/+ and Hhip +/− mice exposed to chronic CS, these differences did not reach statistical significance in either group despite known and controlled exposure to cigarette smoke.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.