Enhanced disease reduction using clozapine, an atypical antipsychotic agent, and glatiramer acetate combination therapy in experimental autoimmune encephalomyelitis.

While there appeared to be an increase in activated microglia between the vehicle-treated immunized compared to unimmunized groups, this difference did not reach statistical significance ( Figure 5(e) ; p = 0.0993 by one-way ANOVA with Tukey’s post-test.) Treatment with clozapine had a profound impact on the number of CD4 T cells, CD8 T cells, and macrophages while the numbers of activated and unactivated microglia were unaffected ( Figure 5(a) to ( f )).

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